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Troponin is a complex of three proteins (troponin C, troponin I, and troponin T) that regulate skeletal and cardiac muscle contraction. Measurement of cardiac troponin I and T can indicate of myocardial damage as their blood levels rise in relation to the extent of injury to heart muscle such as drug-induced cardiotoxicity or cardiovascular disease. 

Troponin I has three separate isoforms in mice, rats, and humans: two in skeletal muscle fibers, and one in cardiac muscle. The cardiac isoform (cTnI) has a molecular weight of 22.5 kdaltons and is about 40% different from other skeletal isoforms.