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TNF-sR2 (Tumor Necrosis Factor Soluble Receptor II)


The 55-kD TNFαR1 and 75-kD TNF αR2 are specific cell surface receptors for TNF α, an inflammatory- mediating cytokine, that elicits TNF-mediated responses through activation of cell signaling pathways. TNF α and its receptors are shed from the cell surface, with TNF α appearing in the plasma as free cytokine or bound to circulating receptors released into the extracellular space. Circulating concentrations of TNF αRII have been found to be associated with cardiovascular and renal disease, and particularly with the development of chronic kidney disease in diabetes.

         h TNF-sR2