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C Reactive Protein (CRP) is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is composed of 5 identical, 21,500- molecular weight subunits. CRP mediates activities associated with preimmune nonspecific host resistance. CRP shows the strongest association with cardiovascular events. It is detectable on the surface of about 4% normal peripheral blood lymphocytes. Acute phase reactant CRP is produced in the liver. C-reactive protein (CRP) is so named because it is able to effect precipitation of somatic C- polysaccharide of Streptococcus pneumonia. The levels in serum rise quickly following acute tissue damage and also falls very rapidly once the stimulus is removed It has been proposed that the function of CRP is to aid in complement activation, influence phagocytic cell function, and augment cell mediated cytotoxicity.