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The ultrafiltration function of the glomerular basement membrane (GBM) of the kidney is impaired in genetic and acquired diseases that affect type IV collagen. It has been shown that high urinary excretion of type IV collagen is associated with deterioration of renal function in type 2 diabetic patients without overt proteinuria as well as nondiabetic kidney disease. Measurement of type IV collagen may be a critical marker in renal function.