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BETA-IG-H3

 βig-h3  (beta-induced gene h3) is a 68 kD protein induced in diverse cell types by Transforming Growth Factor-ß (TGF-ß) that is secreted into the extra-cellular matrix and is involved in cell growth, differentiation, adhesion, and wound healing. ßig-h3 expression is altered in various conditions including tumorigenesis, breast cancer, corneal dystrophy, osteogenesis, and atherothrombosis. ßig-h3 is elevated in the urine of patients with cyclosporine nephrotoxicity and with type 2 diabetes in whom it shows positive correlation with the albumin excretion rate, making it a useful biomarker of renal dysfunction due to diabetes in its earliest phases and in monitoring clinical progression of diabetic nephropathy.